Intent-to-treat vs. Non-intent-to-treat Analyses under Treatment Non-adherence in Mental Health Randomized Trials
نویسندگان
چکیده
منابع مشابه
Exacerbations and intent-to-treat analyses in randomised trials.
In 1998 during a flight from Athens (Greece) to San Francisco (CA, USA), A.M. Hanson, an asthmatic doctor aged 52 yrs, died due to an asthmatic reaction to second-hand cigarette smoke. In 2004, the US Supreme Court ruled that Olympic Airways was to pay the widow of A.M. Hanson US$1.4 million. This successful lawsuit by a passenger against an airline over smoking was unprecedented, and smoking o...
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PURPOSE To describe dropout rates for the intent-to-treat and per protocol analyses from prospective clinical trials. METHODS Review of prospective multi-center parallel studies of 100 patients or more from 1996 onwards. RESULTS We identified 33 articles (70 treatment arms) that fit the criteria for this study. No statistical differences in dropout rates were observed among drug classes for...
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This paper describes some of the statistical considerations in the intent-to-treat design and analysis of clinical trials. The pivotal property of a clinical trial is the assignment of treatments to patients at random. Randomization alone, however, is not sufficient to provide an unbiased comparison of therapies. An additional requirement is that the set of patients contributing to an analysis ...
متن کاملThe role of intention-to-treat analyses in randomized trials.
To the Editor—Fritz et al recently examined 4 different approaches to eradicating Staphylococcus aureus carriage among patients with community-onset skin and soft-tissue infections (SSTIs). The increasing incidence of SSTIs—especially in the context of community-associated methicillin-resistant S. aureus—and the relative paucity of data on this subject make this an important investigation. The ...
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AIM To examine the extent to which the theory of planned behavior (TPB) predicts academic clinicians' intent to treat pediatric obesity. METHODS A multi-disciplinary panel iteratively devised a Likert scale survey based on the constructs of the TPB applied to a set of pediatric obesity themes. A cross-sectional electronic survey was then administered to academic clinicians at tertiary care ce...
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ژورنال
عنوان ژورنال: Psychiatric Annals
سال: 2008
ISSN: 0048-5713,1938-2456
DOI: 10.3928/00485713-20081201-10